Genetic Insights: Avoid These Drugs to Prevent Migraines

Research Summary

A recent study published in Brain and Behavior explores the intersection of genetic data and medication use to identify drugs that might exacerbate migraines. Researchers used data from the UK Biobank and FinnGen to uncover medications, particularly diuretics and drugs acting on the renin-angiotensin system, that are associated with an increased risk of migraines, including those with aura. They identified 37 and 22 target genes linked to these contraindicated medications for migraines and migraines with aura, respectively. Key genes such as BLM, C12orf76, and GPATCH4 were validated through various genetic analyses, offering potential new strategies for preventing migraines and their subtypes.

Study Details

📄 Title: Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches.

👥 Research Team: Wang N et al.

📚 Published In: Brain Behav

📅 Publication Date: 2025 Nov

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.