Gut-Brain Link: Key Differences in Episodic vs. Chronic Migraine
- MigraineMind
- 3 days ago
- 1 min read
Research Summary
Researchers discovered distinct differences in gut-brain axis dysregulation between episodic migraine (EM) and chronic migraine (CM) using nitroglycerin-induced mouse models. The study revealed that mice with CM experienced significant reductions in food intake and body weight, along with shortened colon length. Molecular analyses showed that EM was associated with increased proinflammatory cytokines, while CM exhibited elevated anti-inflammatory cytokines, particularly in the colon. Additionally, calcitonin gene-related peptide (CGRP) levels were markedly upregulated in the gastrointestinal tract of CM mice. Immune profiling indicated divergent immune cell patterns, suggesting more severe dysregulation in CM. These findings support gut-targeted therapies for chronic migraine.
Study Details
👥 Research Team: Shin DC et al.
📚 Published In: Int J Mol Sci
📅 Publication Date: 2025 Oct 29
⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.