Herbal Remedy Eases Migraines by Targeting Brain Pathways

Research Summary

In a recent study published in the Journal of Ethnopharmacology, researchers explored the effects of Puerariae Lobatae Radix (PLR) and Gastrodiae Rhizoma (GR) on nitroglycerin-induced chronic migraine in rats. These traditional Chinese medicine components, known for treating headaches, were shown to regulate weight, pain threshold, and various plasma contents linked to migraine. The study revealed that PLR-GR reduced inflammatory brain factors and protected neuronal cells in the prefrontal cortex and thalamus. By modulating the p38 MAPK/CREB signaling pathway, PLR-GR normalized neurotransmitter and lipid levels, demonstrating a potential mechanism for alleviating migraine damage.

Study Details

📄 Title: Puerariae Lobatae Radix-Gastrodiae Rhizoma ameliorates nitroglycerin-induced chronic migraine by modulating p38 MAPK/CREB signaling pathway in the prefrontal cortex-thalamus neural circuit.

👥 Research Team: Wang Z et al.

📚 Published In: J Ethnopharmacol

📅 Publication Date: 2025 Dec 13

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.