High-Dose Biotin Linked to Worsening Chronic Migraines
- MigraineMind
- Dec 27, 2025
- 1 min read
Research Summary
A recent case report published in the International Medical Case Reports Journal reveals that high-dose biotin supplementation may worsen chronic migraines. The study highlights a female patient whose well-managed classic migraines intensified significantly after starting a daily regimen of 10,000 mcg biotin. Her condition deteriorated, resulting in severe daily headaches unresponsive to triptans and increased emergency room visits. Researchers suggest that the biotin may alter mitochondrial energy metabolism, disrupt neurotransmitter synthesis, and increase oxidative stress, triggering migraine exacerbation. Notably, stopping biotin helped the patient return to baseline, experiencing only rare, mild attacks. Further research is needed to understand this potential trigger.
Study Details
👥 Research Team: Sanosi AA
📚 Published In: Int Med Case Rep J
📅 Publication Date: 2025
⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.