Inflammatory Biomarkers: Key to Managing Chronic Migraines

Research Summary

A systematic review published in Annals of Medicine and Surgery explores the role of serum inflammatory cytokines as biomarkers for predicting chronic migraine transformation. Chronic migraine, marked by 15 or more headache days per month, often evolves from episodic migraine, and inflammation is a key factor. Reviewing nine randomized controlled trials with around 445 participants, the study found elevated pro-inflammatory cytokines like IL-6, IL-1β, and TNF-α in frequent migraine sufferers. Interventions such as omega-3 and nano-curcumin reduced these cytokines and migraine frequency. Although not designed to predict chronic migraine transformation, higher baseline cytokine levels correlated with more frequent migraines, highlighting their potential as both biomarkers and therapeutic targets.

Study Details

📄 Title: Serum inflammatory cytokines as biomarkers for predicting chronic migraine transformation: a systematic review of randomized controlled trials.

👥 Research Team: Syed EUR, Nazar N, Reddy NJ

📚 Published In: Ann Med Surg (Lond)

📅 Publication Date: 2025 Dec

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.