Linking Enlarged Brain Spaces to Chronic Migraine Insights

Research Summary

A recent study published in the Journal of Clinical Neurology explores the link between chronic migraine and enlarged perivascular spaces (EPVS) in the brain, which may indicate glymphatic system dysfunction. Researchers conducted a retrospective case-control study with 44 chronic migraine patients, 44 with episodic migraine, and 39 healthy controls. MRI scans revealed that high-grade EPVS was significantly more prevalent in chronic migraine sufferers, particularly in the centrum semiovale and midbrain. The odds of having high-grade EPVS were notably higher in these regions for chronic migraine patients, suggesting EPVS could serve as an imaging biomarker for chronic migraine.

Study Details

📄 Title: Chronic Migraine Is Associated With Region-Specific High-Grade Enlarged Perivascular Spaces: Retrospective Matched Case-Control Study.

👥 Research Team: Cho JW, Lee GH, Kim J

📚 Published In: J Clin Neurol

📅 Publication Date: 2026 Jan

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.