Migraine and NIID: New Insights from Rare Gene Mutation Study

Research Summary

A recent study published in the journal Clinical Neuropathology explores a case of neuronal intranuclear inclusion disease (NIID) linked to a GGC repeat expansion in the NOTCH2NLC gene. This disorder, known for its diverse symptoms like cognitive dysfunction and peripheral neuropathy, was observed in a 32-year-old Japanese woman with severe episodic symptoms, including hemiplegic migraines and seizures. Her condition, which worsened with right brain edema, led to her being bedridden and eventually passing away from a bloodstream infection. Autopsy revealed unusual astrocytes with cytoplasmic or intranuclear inclusions, suggesting a link between non-neuronal cellular disturbances and episodic symptoms in NIID.

Study Details

📄 Title: Bizarre astrocytes with cytoplasmic/intranuclear inclusions in an individual with alternating hemiplegia, migraine, and brain swelling associated with a GGC repeat expansion in NOTCH2NLC.

👥 Research Team: Yagita K et al.

📚 Published In: Clin Neuropathol

📅 Publication Date: 2025 Nov 14

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.