Migraine Chronification Linked to Precuneus Neurovascular Issues

Research Summary

Researchers found that abnormal neurovascular coupling (NVC) in the brain's precuneus region is associated with the chronification of migraines. In this study published in Cephalalgia, they used advanced imaging techniques to compare cerebral blood flow (CBF) and functional activity in 39 episodic migraine (EM) patients, 61 chronic migraine (CM) patients, and 42 healthy controls. CM patients showed decreased CBF/ReHo ratios, particularly in the right precuneus, which correlated with higher scores for headache impact and depression. Depression mediated the relationship between abnormal NVC and clinical symptoms. The NVC metric could become an imaging feature for diagnosing chronic migraines.

Study Details

📄 Title: Abnormal neurovascular coupling in the precuneus associated with migraine chronification: A multimodal magnetic resonance imaging study.

👥 Research Team: Lin C et al.

📚 Published In: Cephalalgia

📅 Publication Date: 2025 Nov

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.