Migraine Drug Distribution: New Insights from Mouse Study

MigraineMind
Nov 29, 2025
1 min read

Research Summary

A recent study published in Cephalalgia explores the distribution of migraine medications atogepant and rimegepant in mice, offering insights into their mechanisms of action. Researchers used mass spectrometry to track these drugs in various tissues, including plasma, trigeminal ganglion (TG), and brain regions. Atogepant showed a notable pattern, peaking in plasma and TG at three hours, while its brain concentration increased over six hours before dropping. Intriguingly, both drugs accumulated in the dura and hypothalamus similarly to TG. Intranasal delivery of atogepant favored TG accumulation. Unlike oxazepam, neither gepant accumulated in TG or brain cortex after seven days.

Study Details

📄 Title: Biodistribution of atogepant and rimegepant in mouse peripheral and central structures of relevance to migraine pathogenesis.

👥 Research Team: Pistolesi A et al.

📚 Published In: Cephalalgia

📅 Publication Date: 2025 Nov

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.