Monocyte-to-HDL Ratio: Key to Understanding Migraine Brain Changes?

Research Summary

A recent study published in Frontiers in Neurology explored the link between the monocyte-to-HDL cholesterol ratio (MHR) and white matter hyperintensities (WMHs) in migraine patients. The research involved 153 migraine patients and 90 healthy controls, examining serum monocyte and HDL levels alongside MRI findings. Results showed migraine patients had significantly higher MHR levels compared to controls. Higher Fazekas scores correlated with increased MHR and monocyte levels, and decreased HDL levels. An MHR above 13.37 predicted WMHs presence with 89% sensitivity and 98% specificity. This study suggests MHR as a potential inflammatory biomarker for cerebral microvascular changes in migraines.

Study Details

📄 Title: Association between monocyte-to-HDL ratio and Fazekas-scaled white matter hyperintensities in migraine patients: a cross-sectional MRI-based study.

👥 Research Team: Yıldoğan AT et al.

📚 Published In: Front Neurol

📅 Publication Date: 2025

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.