Neuron-Derived Vesicles: New Biomarkers for Migraine Insights
- MigraineMind
- Nov 27, 2025
- 1 min read
Research Summary
In a study published in the Journal of Headache and Pain, researchers explored the potential of neuron-derived extracellular vesicles (nEVs) as biomarkers for migraine, particularly in relation to cortical spreading depolarization (CSD), a key event in migraine aura. By analyzing nEVs from mice experiencing CSD, the study identified changes in proteins related to transcriptional/translational regulation, cytoskeletal dynamics, stress response, and metabolism. These findings suggest that the neuronal response to CSD involves more than just inflammatory signaling, highlighting adaptive structural and metabolic changes. The accessibility of nEVs through peripheral fluids positions them as promising tools for understanding and identifying migraine pathophysiology.
Study Details
👥 Research Team: Sever-Bahcekapili M et al.
📚 Published In: J Headache Pain
📅 Publication Date: 2025 Nov 25
⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.