Neuron-Derived Vesicles: New Migraine Biomarkers Discovered
- MigraineMind
- Nov 27, 2025
- 1 min read
Research Summary
In a study published in the Journal of Headache and Pain, researchers explored neuron-derived extracellular vesicles (nEVs) as potential biomarkers for migraine-related brain activity. These nano-sized particles, found in the central nervous system, were isolated from the cortex of mice experiencing cortical spreading depolarization (CSD), a key event in migraine aura. Using mass spectrometry, the team identified significant changes in nEV proteins, revealing adaptive neuronal responses beyond inflammation, including transcriptional regulation, cytoskeletal dynamics, and metabolism. These findings suggest that nEVs could serve as dynamic indicators of neuronal activity in migraines, highlighting their potential for pathophysiological insights and biomarker discovery.
Study Details
👥 Research Team: Sever-Bahcekapili M et al.
📚 Published In: J Headache Pain
📅 Publication Date: 2025 Nov 25
⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.