New Genetic Insights: Drugs to Avoid for Migraine Relief

Research Summary

A recent study published in Brain and Behavior explores contraindicated medications and target genes for migraines using integrated genetic approaches. By analyzing data from the UK Biobank and FinnGen, researchers identified that diuretics and drugs affecting the renin-angiotensin system may increase the risk of migraines and migraines with aura. They used Mendelian randomization, transcriptome-wide association studies, and various sensitivity analyses to validate these findings. Notably, they pinpointed 37 target genes for general migraine and 22 for migraines with aura. Key genes linked to these contraindications include BLM, C12orf76, GPATCH4, PAM, and SERPINC1, suggesting new avenues for preventive migraine strategies.

Study Details

📄 Title: Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches.

👥 Research Team: Wang N et al.

📚 Published In: Brain Behav

📅 Publication Date: 2025 Nov

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.