New Genetic Insights on Migraines: Key Findings from Veteran Study

MigraineMind
Dec 20, 2025
1 min read

Research Summary

A recent study published in Molecular Psychiatry explores the genetic dynamics of migraine among over 433,000 predominantly male Veterans from the Million Veteran Program. The research identified 49 significant genetic loci linked to migraine, with 36 being novel discoveries. Seven of these were confirmed in a previous study. The study found 283 genes associated with migraine, including newly linked genes like MAML3 and TLR4. Notably, there was a 10% heritability of migraine in men and 16% in women. The research also highlighted potential migraine drug targets such as losmapimod. Despite genetic overlaps with PTSD and depression, no causal relationships were found.

Study Details

📄 Title: A multi-ancestry meta genome-wide association study of migraine among veterans: associations with traumatic brain injury, depression, and post-traumatic stress disorder.

👥 Research Team: Gasperi M et al.

📚 Published In: Mol Psychiatry

📅 Publication Date: 2025 Dec 19

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.