New Insights into Hemiplegic Migraine's Cellular Causes

Research Summary

A study published in Clinical Neuropathology explores the case of a 32-year-old Japanese woman with neuronal intranuclear inclusion disease (NIID), a disorder linked to a GGC repeat expansion in the NOTCH2NLC gene. This patient experienced severe episodic symptoms such as hemiplegic migraines and brain swelling, which started at age 16. Neuropathological analysis revealed numerous neuronal intranuclear inclusions and white matter lesions, alongside bizarre astrocytes with eosinophilic inclusions. These findings suggest a potential link between non-neuronal cellular disturbances and episodic symptoms in NIID, providing new insights into the disease’s complex pathology.

Study Details

📄 Title: Bizarre astrocytes with cytoplasmic/intranuclear inclusions in an individual with alternating hemiplegia, migraine, and brain swelling associated with a GGC repeat expansion in NOTCH2NLC.

👥 Research Team: Yagita K et al.

📚 Published In: Clin Neuropathol

📅 Publication Date: 2025 Nov 14

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.