NSAIDs and Migraine: Increased Risk of Femoral Osteonecrosis

Research Summary

A recent study published in Cureus investigates the link between nonsteroidal anti-inflammatory drugs (NSAIDs) and femoral osteonecrosis in migraine patients. Utilizing the TriNetX database, researchers compared migraine sufferers who used NSAIDs like naproxen, aspirin, diclofenac, or ibuprofen, to those who did not. The findings revealed a significant link between NSAID use and increased risk of femoral osteonecrosis, with a risk ratio of 4 for the overall cohort. Separate analyses for males and females also showed similar significant risks. These results raise concerns about the widespread use of NSAIDs for migraine management, due to potential risks of reduced femoral blood flow and ischemia.

Study Details

📄 Title: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Use Is Associated With an Increased Risk of Femoral Osteonecrosis in Migraine Patients: A Retrospective, TriNetX Database-Based Study.

👥 Research Team: Bisiani J, Matos F Jr, Lynch B

📚 Published In: Cureus

📅 Publication Date: 2025 Oct

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.