NSAIDs for Migraines Linked to Osteonecrosis Risk: Study

Research Summary

A recent study published in Cureus reveals a concerning link between the use of common nonsteroidal anti-inflammatory drugs (NSAIDs) for migraine treatment and an increased risk of femoral osteonecrosis. Utilizing the TriNetX database, researchers compared migraine patients aged 18 to 50 who used NSAIDs like naproxen, aspirin, diclofenac, or ibuprofen to those who did not. The study found a statistically significant increased risk of osteonecrosis in NSAID users, with a risk ratio of 3.6 and odds ratio of 3.6. This association was consistent across both male and female cohorts, highlighting potential risks associated with widespread NSAID use for migraines.

Study Details

📄 Title: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Use Is Associated With an Increased Risk of Femoral Osteonecrosis in Migraine Patients: A Retrospective, TriNetX Database-Based Study.

👥 Research Team: Bisiani J, Matos F Jr, Lynch B

📚 Published In: Cureus

📅 Publication Date: 2025 Oct

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.