Parthenolide & Salicin: Promising Migraine Prevention Combo

Research Summary

A recent study published in the journal Pain explores the potential of combining parthenolide (PTL) and salicin (SA) as a preventive treatment for migraines. Researchers examined the effects of PTL and SA, derived from Feverfew and White Willow, respectively, on migraine models in rats. The combination of these compounds, when administered systemically at low doses, effectively prevented acute cephalic mechanical hypersensitivity (MH) in female rats. Daily administration of the combination prevented both chronic ictal and interictal MH and reduced CGRP-immunoreactivity in the trigeminocervical complex (TCC) in both sexes. This suggests an antimigraine effect by blocking afferent inputs during migraines.

Study Details

📄 Title: Association of parthenolide and salicin as a preventive treatment on a migraine model induced by dural inflammatory soup application.

👥 Research Team: Shrivastava R et al.

📚 Published In: Pain

📅 Publication Date: 2026 Feb 1

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.