Partial Rebreathing Device Ineffective for Migraine Aura Relief

Research Summary

A recent study published in Headache explored the potential of a partial rebreathing device for early treatment of migraine with aura. The study aimed to test the efficacy and safety of a carbon dioxide-enriched gas delivery system in managing acute migraine attacks. Conducted across 15 sites in the US and Germany from March 2023 to February 2025, the trial involved 142 participants aged 18-65. Despite initial hopes, the study was terminated early due to a lack of significant effects. Neither the primary nor secondary endpoints showed statistical significance, indicating the device was ineffective in treating migraine with aura.

Study Details

📄 Title: Partial rebreathing is not effective for early treatment of migraine with aura attacks: Results of a double-blind, randomized, controlled trial (PAREMA1).

👥 Research Team: Gaul C, Ferreira S, Johansen T

📚 Published In: Headache

📅 Publication Date: 2025 Nov 21

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.