Partial Rebreathing Ineffective for Migraine Aura Relief

Research Summary

A recent study published in the journal Headache explored the efficacy of a partial rebreathing device for treating migraine with aura. The device aimed to deliver CO₂-enriched gas during the early stages of a migraine attack. Conducted across 15 sites in the US and Germany, the double-blind, randomized trial enrolled 142 participants aged 18-65. Results showed no significant difference between the active and sham groups in achieving pain relief. At 2 hours, 70% of the sham group and 60% of the active group reported no moderate or severe pain. The study concluded that partial rebreathing was ineffective for migraine with aura.

Study Details

📄 Title: Partial rebreathing is not effective for early treatment of migraine with aura attacks: Results of a double-blind, randomized, controlled trial (PAREMA1).

👥 Research Team: Gaul C, Ferreira S, Johansen T

📚 Published In: Headache

📅 Publication Date: 2025 Nov 21

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.