Probiotics Show Promise in Easing Migraine Symptoms

Research Summary

A recent study published in Scientific Reports highlights the potential of probiotics in managing migraines through the gut-brain-trigeminal axis. Researchers explored the effects of Lactobacillus plantarum, Bifidobacterium longum, their combination, and a multi-strain probiotic on rat models of cortical spreading depression (CSD), a common migraine trigger. B. longum notably decreased CSD frequency, while L. plantarum and its combination with B. longum significantly reduced CSD amplitude, indicating a reduction in cortical hyperexcitability. Probiotics also lowered neural firing and altered membrane potentials in trigeminal ganglion neurons, suggesting decreased neuronal excitability and pain signaling. These findings support microbiota-based therapies for migraine prevention.

Study Details

📄 Title: Probiotic modulation of central and peripheral sensitization in a migraine model via the gut-brain-trigeminal axis.

👥 Research Team: Suthivanich P et al.

📚 Published In: Sci Rep

📅 Publication Date: 2025 Nov 20

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.