Probiotics Show Promise in Easing Migraines via Gut-Brain Axis

Research Summary

A recent study published in Scientific Reports highlights the potential of probiotics in modulating migraine-related pathways through the gut-brain-trigeminal axis. Using a rat model of cortical spreading depression (CSD), a key migraine trigger, researchers tested Lactobacillus plantarum, Bifidobacterium longum, their combination, and a multi-strain probiotic formulation. Bifidobacterium longum notably reduced CSD frequency, while Lactobacillus plantarum and its combination with Bifidobacterium longum diminished CSD amplitude, indicating reduced cortical hyperexcitability. Probiotics also decreased total spike counts and hyperpolarized resting membrane potential in trigeminal ganglion neurons, suggesting peripheral desensitization. These findings propose precision-targeted, microbiota-based therapies for migraine prevention.

Study Details

📄 Title: Probiotic modulation of central and peripheral sensitization in a migraine model via the gut-brain-trigeminal axis.

👥 Research Team: Suthivanich P et al.

📚 Published In: Sci Rep

📅 Publication Date: 2025 Nov 20

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.