Probiotics Show Promise in Reducing Migraine Triggers

Research Summary

A recent study published in Scientific Reports explored how probiotics affect migraine triggers through the gut-brain axis. Using a rat model, researchers investigated the impact of probiotic strains Lactobacillus plantarum, Bifidobacterium longum, their combination, and a multi-strain formulation on cortical spreading depression (CSD), a known migraine trigger. B. longum significantly reduced CSD frequency, while L. plantarum and its combination with B. longum lowered CSD amplitude, indicating reduced brain hyperexcitability. Probiotics also decreased neuron spike counts and increased resting membrane potential thresholds, suggesting peripheral desensitization. These findings support developing microbiota-based, non-drug strategies for migraine prevention.

Study Details

📄 Title: Probiotic modulation of central and peripheral sensitization in a migraine model via the gut-brain-trigeminal axis.

👥 Research Team: Suthivanich P et al.

📚 Published In: Sci Rep

📅 Publication Date: 2025 Nov 20

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.