Progesterone's Role in Chronic Migraine Transformation Unveiled
- MigraineMind
- Dec 7, 2025
- 1 min read
Research Summary
A recent study published in Neurobiology of Disease reveals the role of progesterone receptor (PR) signaling in the transformation from episodic to chronic migraines, particularly in women. Researchers found that female mice were three times more susceptible to chronic migraine transformation than males, experiencing faster pain sensitization and slower recovery. PR agonist segesterone accelerated migraine transformation in females, whereas PR knockout females had slower transformation and quicker recovery. The study showed that PRs in the somatosensory cortex are crucial, as their activation leads to increased pain sensitivity. Chemo-genetically silencing these neurons slowed the transition to chronic migraines, highlighting potential therapeutic targets.
Study Details
👥 Research Team: Joshi S et al.
📚 Published In: Neurobiol Dis
📅 Publication Date: 2025 Dec 4
⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.