Psilocybin’s Potential for Migraine Relief: Study Insights

Research Summary

A study published in Headache explored the effects of psilocybin as a migraine prevention treatment. In this exploratory trial, 18 participants with frequent migraines received either zero, one, or two doses of psilocybin, with diphenhydramine as a placebo. The results showed no significant difference in migraine frequency reduction among the groups, with all groups experiencing a similar reduction of approximately 50% over eight weeks. Although psilocybin showed potential as a transitional migraine treatment, the study's blinding was incomplete, highlighting the need for future research. Importantly, no serious adverse events occurred, emphasizing the safety of the treatment.

Study Details

📄 Title: Comparing single- and repeat-dose psilocybin with active placebo for migraine prevention in an exploratory randomized controlled clinical trial.

👥 Research Team: Schindler EAD et al.

📚 Published In: Headache

📅 Publication Date: 2025 Dec 29

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.