Rare Migraine Case Links Gene Variant to Cerebral Vasospasm

Research Summary

In a recent study published in Translational Pediatrics, researchers present a rare case of familial hemiplegic migraine (FHM) involving cerebral vasospasm and acute encephalopathy linked to an ATP1A2 gene variant. An 11-year-old Asian girl with a 2-year history of FHM experienced an acute episode marked by fever, headache, altered consciousness, and right-sided weakness. Imaging revealed left cerebral cortical swelling and dynamic cerebral vasospasm, which resolved spontaneously. A specific ATP1A2 gene mutation, inherited from her mother, was identified. This case highlights a unique instance of internal carotid artery vasospasm in FHM, enhancing our understanding of its clinical manifestations.

Study Details

📄 Title: Familial hemiplegic migraine type 2 with cerebral vasospasm and acute encephalopathy caused by an ATP1A2 gene variant: a case report.

👥 Research Team: Liu M, Song Z, Ding C

📚 Published In: Transl Pediatr

📅 Publication Date: 2025 Nov 30

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.