Rare Migraine Variant Linked to Gene Mutation in Young Girl

MigraineMind
Dec 11, 2025
1 min read

Research Summary

A recent case study published in Translational Pediatrics sheds light on a rare variant of hemiplegic migraine (HM) linked to a genetic mutation. An 11-year-old Asian girl with familial HM experienced severe symptoms including fever, headache, altered consciousness, and right-sided weakness. This episode was marked by cerebral vasospasm and acute encephalopathy, captured through advanced imaging techniques. The child was found to carry a heterozygous c.2464G>A (p.Glu822Lys) variant in the ATP1A2 gene, inherited from her mother. This case uniquely documents internal carotid artery vasospasm in HM, offering new insights into the migraine's clinical and genetic complexities.

Study Details

📄 Title: Familial hemiplegic migraine type 2 with cerebral vasospasm and acute encephalopathy caused by an ATP1A2 gene variant: a case report.

👥 Research Team: Liu M, Song Z, Ding C

📚 Published In: Transl Pediatr

📅 Publication Date: 2025 Nov 30

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.