Reevaluating Migraine Models: Beyond Spreading Depression

Research Summary

A recent paper published in the Journal of Headache and Pain critically evaluates the canonical spreading depression (SD) model's relevance to migraine. The authors argue against its clinical applicability, emphasizing that while SD is widely regarded as a mechanism for migraine aura, its role in migraine without aura remains unproven. The paper highlights significant gaps in evidence connecting SD to the broader spectrum of migraine symptoms and treatment outcomes. Consequently, the authors suggest the need for more comprehensive models that better reflect the complexity of migraine experiences, potentially paving the way for more effective therapeutic strategies.

Study Details

📄 Title: Is canonical SD a clinically relevant model of migraine? Argument con.

👥 Research Team: Alpay B, Vuralli D, Bolay H

📚 Published In: J Headache Pain

📅 Publication Date: 2025 Dec 3

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.