Stress's Role in Migraine and Chronic Pain Interconnection

Research Summary

A recent study published in the journal Headache explores the significant role stress plays in the comorbidity of chronic migraine and other chronic primary pain conditions like fibromyalgia syndrome (FMS), temporomandibular disorders (TMD), and irritable bowel syndrome (IBS). The research highlights how stress impacts the pathophysiological mechanisms associated with these disorders, suggesting shared mechanisms such as hypothalamic-pituitary-adrenal axis dysfunction, autonomic nervous system dysregulation, and central sensitization. The study emphasizes the importance of preclinical stress-induced models for understanding these mechanisms. While stress-targeted therapies show promise, their precise mechanisms and effectiveness need further investigation to improve patient care.

Study Details

📄 Title: The role of stress in the comorbidity of migraine and other chronic primary pain.

👥 Research Team: Zhao SJ et al.

📚 Published In: Headache

📅 Publication Date: 2025 Nov 26

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.