Tear Fluid Biomarker: Unlocking Migraine Diagnosis Potential

Research Summary

Researchers have found that tear fluid levels of calcitonin gene-related peptide (CGRP), a key player in migraine pathophysiology, rise during headaches induced by glyceryl trinitrate (GTN). In a study published in The Journal of Headache and Pain, 26 episodic migraine patients and 20 healthy controls were examined, revealing significantly higher interictal tear fluid CGRP levels in migraine sufferers. During GTN-induced headaches, tear fluid CGRP levels increased, particularly in those experiencing more severe pain. Importantly, the use of abortive medication significantly reduced these levels compared to spontaneous headache relief. This study underscores the potential of tear fluid CGRP as a migraine biomarker.

Study Details

📄 Title: Tear fluid CGRP rises during glyceryl trinitrate-induced headache in migraine patients.

👥 Research Team: Kamm K et al.

📚 Published In: J Headache Pain

📅 Publication Date: 2025 Nov 14

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.