Tear Fluid CGRP: A New Marker for Migraine Severity Insights

Research Summary

In a study published in The Journal of Headache and Pain, researchers explored the role of tear fluid calcitonin gene-related peptide (CGRP) in migraine sufferers using a glyceryl trinitrate (GTN) model. The study found that interictal tear fluid CGRP levels were higher in episodic migraine (EM) patients compared to healthy controls. During GTN-induced headaches, CGRP levels rose significantly, especially in those experiencing severe headaches. Additionally, CGRP levels decreased more significantly after taking abortive medication than with spontaneous headache relief. These findings confirm the effectiveness of measuring tear fluid CGRP levels during experimental migraines and highlight its potential in understanding migraine pathophysiology.

Study Details

📄 Title: Tear fluid CGRP rises during glyceryl trinitrate-induced headache in migraine patients.

👥 Research Team: Kamm K et al.

📚 Published In: J Headache Pain

📅 Publication Date: 2025 Nov 14

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.