Unlocking CGRP's Role in Migraine Pain: New Insights

Research Summary

A recent study published in Brain uncovers how calcitonin gene-related peptide (CGRP) contributes to migraine pain. Researchers used intra-carotid infusion in rats to target cranial tissues, finding that CGRP activated 62% of Aδ-fibers and 56% of C-fibers, with increased firing rates within 30 minutes and one hour, respectively. Additionally, 75% of central trigeminovascular neurons were activated, leading to increased spontaneous firing and sensitization of dural and facial areas. Local anesthetic blocked CGRP's effects when applied before, but not after, infusion. These findings highlight the potential for early, peripheral CGRP-targeted treatments for migraines, showing no significant sex differences.

Study Details

📄 Title: Elucidating the nociceptive role of CGRP in migraine headache.

👥 Research Team: Melo-Carrillo A, Strassman A, Burstein R

📚 Published In: Brain

📅 Publication Date: 2026 Jan 8

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.