Unraveling Migraine Genetics: Key Variants and Breakthroughs

Research Summary

A recent study published in Nature Communications delves into the genetic underpinnings of migraine, a common neurovascular disorder. By analyzing data from over 98,000 migraine sufferers and nearly 870,000 controls, researchers identified 122 independent risk loci, including 35 new ones. Utilizing a fine-mapping technique, they focused on 102 autosomal risk regions and successfully produced high-quality mappings for 93 of them, defining 181 distinct credible sets. Notably, they pinpointed 7 variants with a very high likelihood of being causal, and 2 significant missense variants in the NGF and INPP5A genes. Impressively, 35 association signals were narrowed down to a maximum of 5 variants each.

Study Details

📄 Title: Fine-mapping a genome-wide meta-analysis of 98,374 migraine cases identifies 181 sets of candidate causal variants.

👥 Research Team: Hautakangas H et al.

📚 Published In: Nat Commun

📅 Publication Date: 2026 Jan 12

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.