Vessel-to-Neuron Link: New Insights into Migraine Causes

Research Summary

Researchers discovered that migraine pain may be initiated by a "vessel-to-neuron" mechanism, integrating both vascular and neuronal theories of migraine pathogenesis. Neurosurgical evidence shows that stimulating or distending intracranial arteries can induce migraine-like pain, highlighting the role of these vessels in migraine development. The activation of the trigeminovascular system and subsequent release of neuropeptides lead to neurogenic inflammation, vasodilation, and sensitization of pain receptors. Molecular migraine triggers, which dilate intracranial vessels, cause potassium efflux that alters local chemical gradients, activating pain pathways. Therapeutic strategies blocking vasodilatory signals or constricting arteries effectively prevent migraines, underscoring vascular contributions.

Study Details

📄 Title: The vessel-to-neuron trigeminovascular hypothesis of migraine pathogenesis - the 'pro' argument.

👥 Research Team: Christensen RH, Ashina H, Ashina M

📚 Published In: J Headache Pain

📅 Publication Date: 2025 Nov 10

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.