Migraine Pathophysiology Research
Explore migraine mechanisms, including cortical spreading depression, trigeminovascular biology, imaging and sensory processing.
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Cortical Spreading Depression Mimicking Ischemic Stroke: A Case Report of Complex Hemiplegic Migraine with Reversible Cortical Magnetic Resonance Imaging Changes.
Authors: Hammed A, Hammed S, Stein T, Niemöller U, Meyer M Case report / case series
A 66-year-old man experienced a rare type of migraine called hemiplegic migraine. This migraine caused him to have sudden weakness on his left side and trouble speaking. His symptoms looked similar to a stroke, which…
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The role of Kynurenine-Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) axis in migraine pathophysiology and therapy.
Authors: Körtési T, Ajkay-Donáth L, Vágvölgyi-Sümegi E, Tapody Z, Varga N Review
Migraine is a common headache disorder, but its exact causes remain unclear. Researchers have traditionally focused on serotonin, but new studies highlight a different pathway. This pathway involves tryptophan…
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Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain
Authors: Noseda et al. Review
Migraine involves inherited changes in brain excitability and pain pathways. The trigeminovascular pathway plays a key role in migraine development. Intracranial arterial dilation contributes to migraine symptoms as…
MigraineMind Top 100 · #34 -
Suppression of cortical spreading depression in migraine prophylaxis
Authors: Ayata et al. Review
Topiramate, valproate, propranolol, amitriptyline, and methysergide are commonly used for migraine prevention. However, their exact action mechanisms remain uncertain. Cortical spreading depression (CSD) is linked to…
MigraineMind Top 100 · #86 -
A Cacna1a Knockin Migraine Mouse Model with Increased Susceptibility to Cortical Spreading Depression
Authors: Maagdenberg et al. Laboratory / animal study
Migraine is a common and disabling neurovascular disorder with unknown causes. One subtype is familial hemiplegic migraine type 1, caused by mutations in the CACNA1A gene. This gene encodes a key subunit of calcium…
MigraineMind Top 100 · #70