Acute migraine treatments in patients above age 65.

Migraine is common and disabling in older adults. However, research on treatment options for those over 65 years is limited. This age group often faces unique challenges, including special considerations for management. Factors like age-related pharmacokinetic changes and comorbidities can complicate treatment. Older patients also have a higher risk of medication-related side effects. This narrative review discusses the current acute treatments available for migraines. It emphasizes the importance of assessing vascular risks, polypharmacy, and kidney function. The review also highlights delayed gastric emptying and impaired liver metabolism as significant factors. The authors analyzed relevant studies from PubMed and Google Scholar between February and March 2025. They provide a breakdown of medication classes, such as non-steroidal anti-inflammatory drugs and triptans. Effective migraine management in older adults requires understanding evidence, addressing gaps, and promoting shared decision-making. More data and guidelines are necessary for informed treatment decisions. Clinical relevance: This research highlights the need for careful migraine management in older adults, considering unique challenges and potential risks.