Acute Migraine Treatment Research
Explore research on acute migraine treatment, including triptans, gepants, ditans, rescue treatment and treatment timing.
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Efficacy and exploratory treatment-response modeling of acupuncture for acute migraine based on DIA proteomics: a study protocol for a randomized controlled trial.
Authors: Zhang Q, Liu M, Xu F, Jiang H Study protocol
r acute migraine and explore treatment-response modeling using proteomics. The research will involve a randomized controlled trial design. Participants will receive acupuncture to assess its impact on migraine…
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Time Course of Rimegepant Effect for Acute Treatment of Migraine in Adults Unsuitable for Triptans: Exploratory Endpoints from a Phase 4, Randomized, Double-Blind, Placebo-Controlled Study.
Authors: Lanteri-Minet M, Smith T, Nalpas C, Ramirez LM, Thiry A Clinical trial
A recent study explored the effects of rimegepant for treating migraines. This trial focused on adults who cannot use triptans. Participants received a single dose of rimegepant 75 mg or a placebo. The study measured…
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Comparative efficacy of AAC and ibuprofen versus lasmiditan, ubrogepant, and rimegepant for the acute treatment of episodic migraine in adults: a systematic review and network meta-analysis.
Authors: Mitra A, Franks B, Petruschke R, Dhiman A, Bansal N Systematic review / meta-analysis
This study compares the effectiveness of over-the-counter (OTC) migraine treatments with newer prescription medications. Researchers analyzed data from 25 randomized controlled trials (RCTs). They focused on how well…
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Effectiveness of Rimegepant for the Acute Treatment of Migraine Among Participants Using Different Types of Preventive Therapy: Analyses from CONFIDENCE.
Authors: Lipton RB, Goadsby PJ, Pozo-Rosich P, Urani A, Lambru G Observational study
This study looked at how well rimegepant works for treating migraines. Researchers focused on patients using different preventive medications. The study involved participants in the United States who had 3-14…
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Efficacy and safety of Dingluo nasal drops for the acute treatment of migraine: a pilot randomized trial.
Authors: Yuning Y, Yuqiu AN, Jiaojiao L, Boxuan DU, Kegang C Clinical trial
This study evaluated the effectiveness and safety of Dingluo nasal drops for treating migraines. Researchers conducted a trial with 91 participants who had 257 migraine attacks. Participants were randomly assigned to…
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[Triptan treatment in migraine: a dose-based model for persistence and acute medication use patterns using nationwide health insurance data].
Authors: Lubik Á, Tibold A, Blasszauer C, Reibl D, Komka I Observational study
This research examined how patients in Hungary use triptans for migraine treatment. Researchers analyzed data from 7840 patients who had never used triptans before. They looked at medication use over three-month…
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Effectiveness and safety of sumatriptan 85 mg/naproxen sodium 500 mg combination for acute migraine: prospective real-world evidence from the GRASP Study Group.
Authors: Rikos D, Argyriou AA, Dermitzakis EV, Soldatos P, Dimisianos N Observational study
This study explored how effective and safe a combination of sumatriptan and naproxen is for treating migraines. The research involved 111 patients who experienced multiple migraine attacks. Each patient received the…
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Acute migraine treatments in patients above age 65.
Authors: Shah T, Ailani J, Dougherty C, Nandyala A Review
Migraine is common and disabling in older adults. However, research on treatment options for those over 65 years is limited. This age group often faces unique challenges, including special considerations for…
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Magnitude and Determinants of Placebo Response in Acute Migraine Trials: A Systematic Review and Meta-Analysis.
Authors: Makita LM, Katsuyama E, Christensen RH, Takeshima T, Ashina S Systematic review / meta-analysis
Migraine is a common and debilitating neurological disorder affecting many people. This study examined the placebo response in acute migraine clinical trials. Researchers analyzed 126 randomized controlled trials…
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Patient Experience with 10 mg Intranasally Administered Zavegepant as an Acute Treatment of Migraine Attacks: Qualitative Research Findings.
Authors: Rosen N, Moran H, Coulter J, Kissling A, You W Observational study
Migraine is a significant burden on individuals and healthcare systems alike. This study investigates patient experiences with zavegepant 10 mg intranasal for acute migraine treatment. Adults with self-reported…
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Safety and tolerability of transnasal evaporative cooling for the acute treatment of migraine in an at-home setting: A randomized, double-blind, sham-controlled, decentralized clinical trial.
Authors: Mays M, Fanning KM, Tepper SJ Clinical trial
Transnasal evaporative cooling (TNEC) may help manage migraine symptoms. This study assessed TNEC's safety and tolerability in adults with migraine. It took place in the U.S. from November 2023 to June 2024…
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[Pharmacological characteristics and clinical outcomes of Rimegepant (Nurtec<sup>®</sup> ODT), an oral CGRP receptor antagonist for the acute treatment and prevention of migraine].
Authors: Ishikawa T, Morota S, Shi B, Li Y, Iijima M Review
Migraine is a common neurological disorder that causes significant burden on individuals. Current treatments face challenges like contraindications and delayed effectiveness. Rimegepant is a new oral medication…
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Acute treatment of migraine in children aged 6-11: Real-world analysis of remote electrical neuromodulation (REN).
Authors: Werner K, Gerson T, Stark-Inbar A, Shmuely S, Ironi A Clinical trial
Migraine affects many children and adolescents, causing significant challenges in their lives. Currently, only one medication is approved for treating migraines in kids aged 6-12. Remote electrical neuromodulation…
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The Acute Treatment of Migraine in Adults: The <scp>A</scp> merican <scp>H</scp> eadache <scp>S</scp> ociety Evidence Assessment of Migraine Pharmacotherapies
Authors: Marmura et al. Review
This study reviews evidence for medications used to treat acute migraine attacks. It updates previous guidelines from the American Academy of Neurology published in 2000. A comprehensive literature search identified…
MigraineMind Top 100 · #65 -
Acute Migraine Medications and Evolution From Episodic to Chronic Migraine: A Longitudinal Population‐Based Study
Authors: Bigal et al. Observational study
This study explores how acute migraine medications affect the transition from episodic migraine (EM) to chronic migraine (TM). Researchers followed 8219 EM patients over five years. They found that 2.5% developed TM…
MigraineMind Top 100 · #49 -
The Triggers or Precipitants of the Acute Migraine Attack
Authors: Kelman Review
This study aimed to identify triggers for acute migraine attacks. Patients rated their triggers on a scale from zero to three. The research included 1,207 patients diagnosed with migraines. About 76% of participants…
MigraineMind Top 100 · #42 -
Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine
Authors: Olesen et al. Clinical trial
Calcitonin gene-related peptide (CGRP) is linked to migraine attacks. Researchers tested a CGRP-receptor antagonist, BIBN 4096 BS, for treating migraines. This trial involved 126 patients who received either placebo…
MigraineMind Top 100 · #20 -
Oral triptans (serotonin 5-HT1B/1D agonists) in acute migraine treatment: a meta-analysis of 53 trials
Authors: Ferrari et al. Systematic review / meta-analysis
Oral triptans, serotonin 5-HT(1B/1D) agonists, are effective acute migraine treatments. Seven types of triptans will soon be available, necessitating evidence-based selection guidelines. We analyzed data from 53…
MigraineMind Top 100 · #40