Acute Migraine Treatment Research

Explore research on acute migraine treatment, including triptans, gepants, ditans, rescue treatment and treatment timing.

1. Effectiveness and safety of sumatriptan 85 mg/naproxen sodium 500 mg combination for acute migraine: prospective real-world evidence from the GRASP Study Group.

   Front Neurol | 2026

   Authors: Rikos D, Argyriou AA, Dermitzakis EV, Soldatos P, Dimisianos N Observational study

   This study explored how effective and safe a combination of sumatriptan and naproxen is for treating migraines. The research involved 111 patients who experienced multiple migraine attacks. Each patient received the…

2. Acute migraine treatments in patients above age 65.

   Headache | 2026

   Authors: Shah T, Ailani J, Dougherty C, Nandyala A Review

   Migraine is common and disabling in older adults. However, research on treatment options for those over 65 years is limited. This age group often faces unique challenges, including special considerations for…

3. Magnitude and Determinants of Placebo Response in Acute Migraine Trials: A Systematic Review and Meta-Analysis.

   Neurology | 2026

   Authors: Makita LM, Katsuyama E, Christensen RH, Takeshima T, Ashina S Systematic review / meta-analysis

   Migraine is a common and debilitating neurological disorder affecting many people. This study examined the placebo response in acute migraine clinical trials. Researchers analyzed 126 randomized controlled trials…

4. Patient Experience with 10 mg Intranasally Administered Zavegepant as an Acute Treatment of Migraine Attacks: Qualitative Research Findings.

   Neurol Ther | 2026

   Authors: Rosen N, Moran H, Coulter J, Kissling A, You W Observational study

   Migraine is a significant burden on individuals and healthcare systems alike. This study investigates patient experiences with zavegepant 10 mg intranasal for acute migraine treatment. Adults with self-reported…

5. Safety and tolerability of transnasal evaporative cooling for the acute treatment of migraine in an at-home setting: A randomized, double-blind, sham-controlled, decentralized clinical trial.

   Headache | 2026

   Authors: Mays M, Fanning KM, Tepper SJ Clinical trial

   Transnasal evaporative cooling (TNEC) may help manage migraine symptoms. This study assessed TNEC's safety and tolerability in adults with migraine. It took place in the U.S. from November 2023 to June 2024…

6. [Pharmacological characteristics and clinical outcomes of Rimegepant (Nurtec^® ODT), an oral CGRP receptor antagonist for the acute treatment and prevention of migraine].

   Nihon Yakurigaku Zasshi | 2026

   Authors: Ishikawa T, Morota S, Shi B, Li Y, Iijima M Review

   Migraine is a common neurological disorder that causes significant burden on individuals. Current treatments face challenges like contraindications and delayed effectiveness. Rimegepant is a new oral medication…

7. Acute treatment of migraine in children aged 6-11: Real-world analysis of remote electrical neuromodulation (REN).

   Ann Child Neurol Soc | 2024

   Authors: Werner K, Gerson T, Stark-Inbar A, Shmuely S, Ironi A Clinical trial

   Migraine affects many children and adolescents, causing significant challenges in their lives. Currently, only one medication is approved for treating migraines in kids aged 6-12. Remote electrical neuromodulation…

8. The Acute Treatment of Migraine in Adults: The <scp>A</scp> merican <scp>H</scp> eadache <scp>S</scp> ociety Evidence Assessment of Migraine Pharmacotherapies

   Headache The Journal of Head and Face Pain | 2015

   Authors: Marmura et al. Review

   This study reviews evidence for medications used to treat acute migraine attacks. It updates previous guidelines from the American Academy of Neurology published in 2000. A comprehensive literature search identified…

   MigraineMind Top 100 · #65
9. Acute Migraine Medications and Evolution From Episodic to Chronic Migraine: A Longitudinal Population‐Based Study

   Headache The Journal of Head and Face Pain | 2008

   Authors: Bigal et al. Observational study

   This study explores how acute migraine medications affect the transition from episodic migraine (EM) to chronic migraine (TM). Researchers followed 8219 EM patients over five years. They found that 2.5% developed TM…

   MigraineMind Top 100 · #49
10. The Triggers or Precipitants of the Acute Migraine Attack

    Cephalalgia | 2007

    Authors: Kelman Review

    This study aimed to identify triggers for acute migraine attacks. Patients rated their triggers on a scale from zero to three. The research included 1,207 patients diagnosed with migraines. About 76% of participants…

    MigraineMind Top 100 · #42
11. Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine

    New England Journal of Medicine | 2004

    Authors: Olesen et al. Clinical trial

    Calcitonin gene-related peptide (CGRP) is linked to migraine attacks. Researchers tested a CGRP-receptor antagonist, BIBN 4096 BS, for treating migraines. This trial involved 126 patients who received either placebo…

    MigraineMind Top 100 · #20
12. Oral triptans (serotonin 5-HT1B/1D agonists) in acute migraine treatment: a meta-analysis of 53 trials

    The Lancet | 2001

    Authors: Ferrari et al. Systematic review / meta-analysis

    Oral triptans, serotonin 5-HT(1B/1D) agonists, are effective acute migraine treatments. Seven types of triptans will soon be available, necessitating evidence-based selection guidelines. We analyzed data from 53…

    MigraineMind Top 100 · #40