MigraineMind research summary
Real-world assessment of effectiveness and safety of candesartan in migraine prevention: Results of the French FHU InovPain registry.
Rev Neurol (Paris) | 2026
Observational studySummary
Candesartan is recommended for migraine prevention, but real-world data is limited. This study analyzed adults starting candesartan in the French FHU InovPain registry. Patients were assessed at month 3, month 9, and month 15. The main goal was the responder rate at month 3. This rate was defined as a 50% reduction in monthly migraine days. In the analysis, 42% experienced this reduction at month 3. A more conservative analysis showed a 37% responder rate. Mean monthly migraine days decreased from 14.1 to 9.7. Among patients on treatment, responder rates were 76% at month 9 and 79% at month 15. Higher responder rates were found in episodic migraine compared to chronic migraine. Treatment-emergent adverse events occurred in 29%, leading to a 16% discontinuation rate. Overall, candesartan significantly reduced migraine burden, emphasizing the need for more studies. Clinical relevance: This research suggests that candesartan effectively reduces migraine frequency, offering hope for patients seeking preventive treatment.
Key Learning Points
- Candesartan may help reduce the frequency of migraines, with a significant number of patients experiencing fewer migraine days.
- In this study, 42% of patients reported at least a 50% reduction in monthly migraine days after three months of treatment.
- Responder rates improved over time, reaching 76% at nine months and 79% at fifteen months.
- Patients with episodic migraines had better outcomes compared to those with chronic migraines.
- While effective, 29% of patients experienced treatment-emergent side effects, leading to a 16% discontinuation rate.
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Original research
Read the original publication and review its full methods and findings on PubMed.
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