Efficacy and safety of Dingluo nasal drops for the acute treatment of migraine: a pilot randomized trial.

This study evaluated the effectiveness and safety of Dingluo nasal drops for treating migraines. Researchers conducted a trial with 91 participants who had 257 migraine attacks. Participants were randomly assigned to receive either a full dose, a half dose, or a placebo. The main goal was to see how many people felt pain relief two hours after using the medication. Results showed that those using the full dose experienced pain relief 14.61% of the time, while only 1.20% of the placebo group did. The half-dose group had a 17.65% success rate, compared to 1.20% for the placebo. Both doses of Dingluo nasal drops were significantly better than the placebo for pain relief. This suggests that Dingluo nasal drops could be a promising option for acute migraine treatment, offering hope for those who suffer from these debilitating headaches. Clinical relevance: This research indicates that Dingluo nasal drops may provide effective acute relief for migraine sufferers, potentially enhancing treatment options available to patients.