Exploratory evaluation of miR-146, inflammatory biomarkers, and subjective cognitive symptoms in chronic migraine.

Chronic migraine (CM) is a condition that significantly affects daily life. This study looked at how certain inflammatory markers relate to cognitive symptoms in CM. Researchers focused on three key markers: HMGB1, IL-17, and miR-146. They collected blood samples from 20 women with CM and 15 healthy women. They also assessed cognitive function using tests like the Mini-Mental State Examination. The researchers found that higher levels of HMGB1 and IL-17 were linked to worse cognitive symptoms. MiR-146 levels also showed some relationship with these symptoms. These findings suggest that inflammation may play a role in cognitive difficulties experienced by CM patients. Understanding these connections could help develop better treatments. Future research may explore how targeting these inflammatory pathways might improve cognitive function in people with chronic migraines. Overall, this study highlights the importance of inflammation in chronic migraine and cognitive health. Clinical relevance: This study indicates that inflammation may worsen cognitive symptoms in chronic migraine patients, suggesting potential new treatment strategies targeting inflammatory pathways to improve cognitive function.