Chronic Migraine Research
Explore research on chronic migraine, migraine chronification, treatment and outcomes.
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COMPARATIVE EFFICACY OF 200 UNITS VERSUS 155 UNITS OF ONABOTULINUMTOXIN A FOR CHRONIC MIGRAINE.
Authors: Alkhaffaf W, Alkataan M Clinical trial
This study looked at how effective different doses of onabotulinumtoxin A (OnaBT-A) are for treating chronic migraine. Chronic migraine affects many people and can be hard to manage. Researchers conducted this study…
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Investigating the mechanism of Xiongfu formula and its active ingredient Z-Ligustilide alleviates chronic migraine by modulating the MAPK/ERK/CREB pathway and microglia-mediated neuroinflammation.
Authors: Zhang Y, Jin L, Liu X, Shi W, Wang Q Laboratory / animal study
Chronic migraine is a painful condition that can disrupt daily life. Traditional Chinese medicine views it as a result of stagnated Qi and poor blood flow. The Xiongfu formula is a classic herbal remedy for…
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Guanfacine as a potential preventive therapy for chronic migraine: a mechanistic hypothesis.
Authors: Kesayan T, Patel K Clinical trial
Guanfacine is a medication that may help prevent chronic migraines. Many patients still struggle with migraines despite existing treatments. About one-third of chronic migraine patients do not find relief. Current…
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OnabotulinumtoxinA Improves Sleep Quality in Patients with Chronic Migraine: A Prospective Real-World Study.
Authors: Viticchi G, Falsetti L, Bartolini M, Salvemini S, De Vanna G Observational study
months of treatment. Researchers found that sleep quality improved significantly in patients after receiving OBT-A. Specifically, 63% of patients reported better sleep after three months. Patients also experienced…
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Sleep and Migraine Interactions in Episodic and Chronic Migraine: A Hospital-Based Cross-Sectional Study.
Authors: Mathur S, Seshagiri DV, Mythirayee S, Mailankody P, Raja P Observational study
Migraine and sleep problems often occur together, affecting many patients. This study looked at 253 migraine patients, including those with episodic and chronic migraines. Researchers measured migraine-related…
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Multimodal 7T MRI reveals subcortical structural, functional, iron accumulation, and glymphatic abnormalities in chronic migraine.
Authors: Wang X, Hu J, Duan C, Xiong Y, Zong X Observational study
Chronic migraine (CM) is a complex condition that affects many people. Researchers used advanced 7T MRI technology to study brain changes in CM patients. They looked at 62 healthy controls, 62 episodic migraine…
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Considerations for understanding systematic reviews and network meta-analyses in neurological applications: a review and critique in chronic migraine.
Authors: Ailani J, Saffore CD, Ubamadu I, Perni S, Chertavian E Systematic review / meta-analysis
Network meta-analysis (NMA) helps compare multiple treatments for chronic migraine. It combines direct and indirect evidence when head-to-head trials are missing. Guidelines exist for conducting and reporting NMAs…
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CD200/CD200R1 activation alleviates central sensitization in chronic migraine via STAT6.
Authors: Li Z, Li D, Fan Z, Cai H, Ge Z Laboratory / animal study
Chronic migraine (CM) involves a process called central sensitization (CS). This process is influenced by microglial activation in the brain. Researchers studied the CD200/CD200R1 pathway, which helps regulate immune…
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Assessment of Cerebral Perfusion Asymmetry in Chronic Migraine Patients Using Intravoxel Incoherent Motion (IVIM)-Derived Pseudodiffusion Coefficient and Perfusion Fraction.
Authors: Senturk YE, Peker A, Yuzkan S, Ergin HE, Bulus E Observational study
Chronic migraine (CM) affects many people and involves changes in the brain. Researchers studied blood flow in the brain during the interictal phase of CM. They used a special MRI technique called IVIM to measure…
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Anti-CGRP Monoclonal Antibodies in Chronic Migraine: A Position Statement of the Brazilian Academy of Headache and Orofacial Pain.
Authors: Krymchantowski A, Júnior HMDS, Silva-Néto RP, Jevoux C, Costa ALC Guideline / consensus
Chronic migraine (CM) is a serious condition affecting many people. It often comes with other health issues and is hard to treat. Recent treatments include anti-calcitonin gene-related peptide (CGRP) monoclonal…
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Exploratory evaluation of miR-146, inflammatory biomarkers, and subjective cognitive symptoms in chronic migraine.
Authors: Gök Dağidir H, Bandirmali D, Ceren Akgör MH, Vuralli D, Yalinay M Observational study
Chronic migraine (CM) is a condition that significantly affects daily life. This study looked at how certain inflammatory markers relate to cognitive symptoms in CM. Researchers focused on three key markers: HMGB1…
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Lidocaine Combined With Platelet-Rich Plasma for Stellate Ganglion Block in Chronic Migraine: A Multicenter, Prospective, Propensity Score-Matched Cohort Study.
Authors: Liu L, Duan B, Ma T, Li L, Yang D Clinical trial
This study looked at a new treatment for chronic migraine. It compared two methods: one using lidocaine alone and the other using lidocaine with platelet-rich plasma (PRP). Researchers enrolled 200 adults with…
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Pharmacotherapy for chronic migraine prevention: a narrative review.
Authors: Baek Y, Yuan H, Silberstein S Review
Chronic migraine (CM) is a serious condition affecting 1-2% of people. It causes significant pain and can disrupt daily life. This research reviews various treatments for preventing CM. The authors examined studies…
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OnabotulinumtoxinA for chronic migraine: A real-life multicenter study of 479 patients.
Authors: Waliszewska-Prosół M, Marschollek K, Paczkowska M, Sławek J, Bott-Karoń M Observational study
Chronic migraine (CM) is a tough condition to treat, especially with medication-overuse headache (MOH). This study looked at how well onabotulinumtoxin A (BoNT-A) works for CM. Researchers studied 479 Polish patients…
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Effectiveness of Onabotulinumtoxin-A in Patients with Chronic Migraine and Previous CGRP-mAb Treatment Failure: A Multicentre 6-Month Real-World Experience.
Authors: Silvestro M, Albanese M, Orologio I, Iannone LF, Pistoia F Observational study
Many patients with chronic migraine (CM) do not respond to standard treatments. Sometimes, they fail to benefit from medications targeting the CGRP pathway. This study looked at onabotulinumtoxin-A (BoNT-A) for these…
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Efficacy and Safety of Oral Zavegepant in Migraine Prevention: A Phase 2/3 Randomized, Double-Blind, Placebo-Controlled Study in Patients with Chronic Migraine.
Authors: Fountaine RJ, Dubrovin S, Mosher L, Liu J, Shahin MH Clinical trial
This study explored the effectiveness and safety of oral zavegepant for chronic migraine prevention. It involved adults with a history of chronic migraines, experiencing many headache days each month. Participants…
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A Three-Point, Low-Dose, Artery-Targeted Botulinum Toxin Treatment for Chronic Migraine: A Randomized, Double-Blind, Contralateral-Controlled Trial.
Authors: Nazari S, Farshi M, Pourani MR, Fakih-Gomez N Clinical trial
Chronic migraine is a common condition affecting many people. This study focused on using low-dose botulinum toxin type A (BoNT-A) to treat it. Researchers wanted to see if targeted injections along migraine-related…
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Cluster Analysis of Global Research Hotspots and Thematic Evolution in Chronic Migraine: A Bibliometric Study (1917-2024).
Authors: Chen H, Chen Q, Yang Y, Yu Q, Pan Y Laboratory / animal study
Chronic migraine is a common and debilitating neurological condition affecting many people. This study examined research trends on chronic migraine from 1917 to 2024. Researchers used cluster analysis to identify…
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A status update on the unkept promise of high-frequency spinal cord stimulation for treatment-refractory chronic migraine.
Authors: Martelletti P, Tana C Case report / case series
Chronic migraine is a challenging condition, especially when treatments fail. High-frequency spinal cord stimulation (HF-SCS) is a new approach for these patients. This method uses a frequency of 10 kilohertz, which…
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Comorbidity of Temporomandibular Disorders, Anxiety, Depression, and Poor Sleep Quality in Episodic and Chronic Migraine: A Cross-Sectional Observational Study.
Authors: Torrijos-Gómez G, Florencio LL, Cuadrado ML, Ardizone I, Porta-Etessam J Observational study
This study looked at the link between temporomandibular disorders (TMD) and migraine. Researchers focused on two types of migraine: episodic migraine (EM) and chronic migraine (CM). They wanted to see if TMD made…