Assessment of Cerebral Perfusion Asymmetry in Chronic Migraine Patients Using Intravoxel Incoherent Motion (IVIM)-Derived Pseudodiffusion Coefficient and Perfusion Fraction.

Chronic migraine (CM) affects many people and involves changes in the brain. Researchers studied blood flow in the brain during the interictal phase of CM. They used a special MRI technique called IVIM to measure blood flow. The study included 30 CM patients and 30 healthy controls. The researchers looked at the differences in blood flow between the right and left sides of the brain. They measured specific parameters related to blood flow, including the pseudodiffusion coefficient and perfusion fraction. This study aimed to understand how these blood flow changes relate to CM. The findings could help researchers learn more about the neurobiological changes in chronic migraine. Understanding these changes may lead to better treatments and management strategies for CM patients. Overall, the study sheds light on the brain's microvascular changes in chronic migraine. Clinical relevance: This research highlights the need for targeted therapies addressing blood flow changes in chronic migraine patients.