Comparative efficacy of AAC and ibuprofen versus lasmiditan, ubrogepant, and rimegepant for the acute treatment of episodic migraine in adults: a systematic review and network meta-analysis.

This study compares the effectiveness of over-the-counter (OTC) migraine treatments with newer prescription medications. Researchers analyzed data from 25 randomized controlled trials (RCTs). They focused on how well these treatments relieve pain within two hours. The study looked at common OTC options, like ibuprofen, against newer drugs like lasmiditan and ubrogepant. They also considered side effects like photophobia, phonophobia, and nausea. The results showed that while OTC treatments are widely used, the newer medications may offer better relief for some patients. The findings can help doctors and patients make informed choices about migraine treatments. More research is needed to fully understand the differences between these therapies. Overall, this analysis provides valuable insights into migraine treatment options for adults, emphasizing the importance of considering both efficacy and safety when selecting a treatment plan. Clinical relevance: This research indicates that newer migraine medications may provide better pain relief than traditional OTC options, guiding treatment choices for patients and clinicians.