Investigating the mechanism of Xiongfu formula and its active ingredient Z-Ligustilide alleviates chronic migraine by modulating the MAPK/ERK/CREB pathway and microglia-mediated neuroinflammation.

Chronic migraine is a painful condition that can disrupt daily life. Traditional Chinese medicine views it as a result of stagnated Qi and poor blood flow. The Xiongfu formula is a classic herbal remedy for migraines. This study explored how this formula works to relieve chronic migraines. Researchers used a rat model to simulate chronic migraine symptoms. They evaluated the effectiveness of the Xiongfu formula through behavioral tests and nerve assessments. Advanced techniques like RNA-seq and western blotting helped identify how the formula affects the body. The study found that the active ingredient, Z-Ligustilide, may help reduce migraine symptoms. It does this by influencing certain biological pathways and reducing inflammation in the brain. These findings suggest that herbal treatments could be effective for chronic migraine relief, potentially offering new options for patients seeking alternatives to conventional medications. Clinical relevance: This research indicates that the Xiongfu formula may provide effective treatment options for chronic migraine patients, potentially enhancing their quality of life through natural remedies.