Real-World Effectiveness and Tolerability of Rimegepant as Second- or Third-Line Acute Treatment for Migraine: A Prospective Observational Study.

Rimegepant is a medication for treating migraines. It works by blocking certain receptors in the brain. This study looked at how well rimegepant works when other treatments fail. Researchers followed 89 patients who had already tried other medications. Most participants were women, and their average age was around 41 years. They took rimegepant after finding triptans or lasmiditan ineffective or unsuitable. Patients rated their headache pain before taking rimegepant and then again after 2 and 4 hours. The study measured pain freedom, which means a complete absence of headache pain. It also looked at significant pain reduction of 50% or more. Results showed that many patients experienced reduced pain and improved overall feelings about their treatment. This suggests rimegepant is a valuable option for those with difficult-to-treat migraines. Clinical relevance: This study indicates that rimegepant is effective for patients with migraines who cannot tolerate other treatments.