Comparative efficacy of vitamins and nutraceuticals for migraine prevention: A systematic review and network meta-analysis of randomized controlled trials.

Migraine affects millions of people worldwide and can be debilitating. Traditional medications may not work well for everyone. Some patients seek alternative treatments like vitamins and nutraceuticals. This research focused on evaluating the effectiveness of these alternatives for preventing migraines. The study reviewed various randomized controlled trials comparing different vitamins and nutraceuticals. They looked at riboflavin, coenzyme Q10, magnesium, and vitamin D3. The goal was to understand which options worked best and were safest. The researchers used a method called network meta-analysis to compare results. They found that some vitamins and nutraceuticals might help reduce migraine frequency. However, more research is needed to confirm these findings and determine optimal dosages. Overall, this study offers insights into potential complementary treatments for individuals struggling with migraines. Clinical relevance: This research highlights potential alternative treatments for migraine prevention, offering options beyond traditional medications.