Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
Browse migraine research by topic
Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Rimegepant for migraine prevention in clinical practice: A multicenter study including patients with prior anti-CGRP monoclonal antibody failure (GEMA project).
Rimegepant is a CGRP receptor antagonist for treating episodic migraines. This study examined rimegepant's effectiveness in patients with previous treatment failures. It was conducted across nine headache units in…
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The association between social risk profile and self-reported severe headache or migraine with all-cause mortality risk: A machine learning-based prediction model and interpretability analysis.
This study investigates how social risk factors affect migraines and mortality. Researchers used data from 11,861 US adults collected between 1999 and 2004. They examined the relationship between social risk profile…
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Thiamine deficiency in patients with chronic migraine: A case-control study.
Thiamine deficiency is noted in various neurological disorders, including chronic migraine (CM). This study aimed to compare serum thiamine levels in CM patients and healthy controls. A total of 100 adults with CM…
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Potential role of tirzepatide, a dual GLP-1 and GIP receptor agonist, for preventive treatment of migraine: A case series.
Obesity often worsens migraine symptoms and increases their frequency and severity. Recent studies indicate that GLP-1 receptor agonists may help in pain modulation. Researchers observed two patients with migraine…
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Adverse childhood experiences, migraine, and adverse pregnancy outcomes among teenage mothers.
This study explored how adverse childhood experiences (ACEs) and migraine relate to pregnancy outcomes. Teenage mothers face higher risks for adverse birth outcomes than adults. The research included 819 Peruvian…
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Effect of chronic migraine treatment on functional seizure frequency: An exploratory study.
Chronic migraine often coexists with functional seizures, which are challenging to manage. This study aimed to see if migraine treatment impacts seizure frequency in patients. Researchers selected patients suffering…
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Trigeminovascular calcitonin gene-related peptide release and peripheral vascular responses in a mouse model of accelerated aging: Implications for migraine.
Understanding age-related changes in migraine is crucial as life expectancy increases. Both aging and migraine are significant cardiovascular risk factors. Researchers studied how calcitonin gene-related peptide…
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Cerebrovascular reactivity in migraine: a breath-hold BOLD fMRI study.
This study focused on cerebrovascular reactivity (CVR) in migraine patients. Previous studies used Doppler ultrasonography, limiting their findings to large vascular areas. New functional MRI techniques offer higher…
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Profile of migraine patients in Middle East and North Africa (MENA) region: a multi-center study.
The Middle East and North Africa (MENA) region faces unique migraine challenges. This study examined differences between migraine patients in low-/lower-middle-income and high-/upper-middle-income countries. It…
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Xiongzhi Qufeng Zhitong Granule alleviates nitroglycerin-induced migraine-like nociception and central neuroinflammation by regulating the HMGB1 / TRPV1 / MAPK signaling axis.
Chronic migraine (CM) is a common neuroinflammatory disorder with few treatment options. Xiongzhi Qufeng Zhitong Granules (XZQF) are a traditional Chinese medicine showing anti-migraine potential. This study explored…
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Weight loss with atogepant in the long-term treatment of migraine: An interim analysis of a safety endpoint from a phase 3, multicenter, open-label, 156-week extension study.
This study examined weight loss with atogepant 60 mg daily for migraine treatment. Participants had chronic or episodic migraine and had previously failed several medications. Obesity increases migraine risk…
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CGRP-Targeted Therapy in Vestibular Migraine-How Strong Is the Evidence?
CGRP-targeted therapies have shown promise in reducing migraine symptoms for many patients. However, evidence for their effectiveness in vestibular migraine is limited and preliminary. Current literature on…
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TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review).
Migraines are common and debilitating neurological disorders affecting many people. Central sensitisation is the main cause of their recurrent and chronic nature. Transient receptor potential vanilloid 1, or TRPV1…
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Long-term neuromuscular alterations during botulinum toxin treatment for chronic migraine.
This study examined the effects of botulinum toxin type A on chronic migraine. Forty women with chronic migraine received varying lengths of BoNTA treatment. Researchers evaluated migraine frequency, pain burden, and…
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Efficacy, tolerability and barriers to the use of anti-CGRP medications among migraine patients in Egypt: real world experience.
This study evaluated the real-world use of anti-CGRP therapies in Egypt. Researchers focused on effectiveness, tolerability, barriers to access, and treatment adherence. Eighty migraine patients participated…
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Migraine relief: Solutions from natural bioactive products of Traditional Chinese medicine.
Migraine is a chronic neurological disorder causing recurrent, pulsating headaches. It often comes with symptoms like visual aura, phonophobia, and gastrointestinal issues. Natural bioactive products from traditional…
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Evaluation of the interrelationship between inflammatory markers, rosacea, ocular symptoms, and migraine comorbidity.
Rosacea is a chronic skin condition linked to ocular symptoms and migraines. This study compared inflammatory and hematological markers in rosacea patients and healthy controls. A total of 150 rosacea patients…
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Cerebrovascular risk with calcitonin gene-related peptide monoclonal antibodies versus onabotulinumtoxinA in patients with migraine: A real-world pharmacoepidemiologic study in the National Institutes of Health All of Us Research Program.
In a study comparing treatments for migraine, researchers evaluated calcitonin gene-related peptide monoclonal antibodies, or CGRP mAbs, and onabotulinumtoxinA. They aimed to determine if CGRP mAbs were non-inferior…
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Efficacy Evaluation of Right-Heart Contrast Echocardiography Combined With the Valsalva Manoeuvre in Screening for Patent Foramen Ovale in Patients With Migraine Without an Identified Secondary Cause.
This study evaluated the effectiveness of right-heart contrast echocardiography (RHCE) with the Valsalva manoeuvre. It focused on screening for patent foramen ovale (PFO) in migraine patients. A total of 232 patients…
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Misophonia, Autistic Traits, and Obsessive-Compulsive Symptoms in Migraine: A Controlled Comparative Study.
This study looked at misophonia in adolescents with migraine compared to controls. It involved 80 participants aged 15-18 years, half with migraine. Researchers used various scales to assess misophonia…