Latest Migraine & Headache Research
MigraineMind provides concise summaries, key learning points and links to the original scientific publications behind recently published migraine and headache research. Learn about MigraineMind or read how the research summaries are made.
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Explore focused collections that currently meet MigraineMind’s five-paper quality threshold.
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Magnitude and Determinants of Placebo Response in Acute Migraine Trials: A Systematic Review and Meta-Analysis.
Migraine is a common and debilitating neurological disorder affecting many people. This study examined the placebo response in acute migraine clinical trials. Researchers analyzed 126 randomized controlled trials…
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Endocannabinoid cerebrospinal fluid levels in migraine and its relation to symptoms of depression.
This study explores the endocannabinoid system's role in migraine and depression. Researchers examined cerebrospinal fluid (CSF) levels of specific endocannabinoids in 194 episodic migraine patients. The participants…
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Real-world outcomes of zavegepant use in a tertiary care setting using the Migraine Treatment Optimization Questionnaire-5.
The introduction of calcitonin gene-related peptide antagonists has changed migraine treatment. Zavegepant is a third-generation intranasal gepant for acute migraine relief. Although clinical trials show its…
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Development and Validation of a Headache Health Education Program to Serve as a Control Intervention for Non-Pharmacological Studies in Migraine.
As interest grows in non-pharmacologic migraine treatments, a suitable control is vital. Designing effective controls for these treatments presents significant challenges. One solution is developing a credible…
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Beyond migraine: A narrative review of photophobia's clinical spectrum.
Photophobia is a common and often disabling symptom in various conditions. It is particularly prevalent in migraine but also seen in common eye diseases. This review explores the complex interactions between visual…
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An orexinergic circuit driving migraine relief by lavender essential oil.
Lavender essential oil (LEO) may provide relief for chronic migraine sufferers. Current pharmacological treatments often lack long-term effectiveness and suitability. Research shows that LEO inhalation activates…
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Patient Experience with 10 mg Intranasally Administered Zavegepant as an Acute Treatment of Migraine Attacks: Qualitative Research Findings.
Migraine is a significant burden on individuals and healthcare systems alike. This study investigates patient experiences with zavegepant 10 mg intranasal for acute migraine treatment. Adults with self-reported…
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Delayed Access Is a Migraine Risk Factor: Precision Triage as the Missing Link in Modern Headache Care.
Migraine care has advanced in precision, yet many patient pathways remain confusing. Many patients face delays in diagnosis and experience underestimated disability. This leads to increased acute medication use…
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Menopausal hormone therapy, migraine history, and headache severity: Results from the Women's Health Initiative Hormone Therapy clinical trials.
This study explored how menopausal hormone therapy affects headache severity in women. Researchers focused on 22,876 postmenopausal women in the Women's Health Initiative trials. They compared the effects of…
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Safety and tolerability of transnasal evaporative cooling for the acute treatment of migraine in an at-home setting: A randomized, double-blind, sham-controlled, decentralized clinical trial.
Transnasal evaporative cooling (TNEC) may help manage migraine symptoms. This study assessed TNEC's safety and tolerability in adults with migraine. It took place in the U.S. from November 2023 to June 2024…
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IL-17A, IL-17RA, and IL-22 as biomarkers in migraine: associations with disease activity and clinical features.
Migraine is increasingly seen as a neuroinflammatory disorder linked to immune processes. This study examined levels of Th17-related cytokines, specifically IL-17A, IL-17RA, and IL-22. Researchers included 99…
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Early and clinically meaningful functional improvement following CGRP monoclonal antibodies in adolescents with migraine: A real-world retrospective study.
CGRP monoclonal antibodies (mAb) could help adolescents with migraines. This study focused on adolescents aged 15-17 years who received CGRP mAb therapy for migraine. It evaluated early functional outcomes in daily…
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The special extract ERr 731<sup>®</sup> from the root of rhapontic rhubarb (<i>Rheum rhaponticum</i>): efficacy in headache/migraine and further climacteric complaints in women in the perimenopause.
Menopause triggers neuroendocrine changes and various climacteric symptoms in women. Hormone replacement therapy (HRT) is the standard treatment but has safety concerns. This study explored ERr 731®, a non-hormonal…
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Combined biofeedback and vestibular rehabilitation therapy for vestibular migraine: clinical efficacy and neurobiochemical correlates.
Vestibular migraine (VM) leads to recurrent vertigo with limited treatment options available. This study explored the combined effects of biofeedback therapy and vestibular rehabilitation. Researchers enrolled 148 VM…
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Investigating the Patent Foramen Ovale-Migraine Link in Southern Saudi Arabia.
Migraine is a disabling neurological condition linked to patent foramen ovale (PFO). This study involved 45 patients from January to April 2024. There were 30 migraine patients with PFO and 15 without PFO. All…
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Migraine and risk of adverse obstetric outcomes: a matched cohort study of English linked electronic health records.
This study explored how pre-pregnancy migraine affects obstetric outcomes in women. Researchers analyzed linked electronic health records from England, focusing on women aged 15-50 years. They evaluated 428,217…
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Peptidomics profiling identifies endogenous peptides associated with meningeal afferent activation in a chronic migraine mouse model.
Migraine is a disabling disorder that affects many people worldwide. It significantly impacts quality of life due to its debilitating symptoms. Recent studies suggest that endogenous peptides play vital roles in…
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Iatrogenic harm in paediatric and adolescent populations of patients with migraine: A systematic review with meta-analysis.
Migraine significantly impacts children and adolescents, causing a high disability burden. The effectiveness of pharmacological treatments remains debated, raising safety concerns among young patients. This study…
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Efficacy of prefrontal-occipital transcranial direct current stimulation for refractory chronic migraine.
Patients with chronic migraine often do not respond to standard medical treatments. This resistance likely comes from the complex nature of their pain. Transcranial direct current stimulation, or tDCS, is a new…
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Three-Year Interim Results from a Post-Marketing Surveillance Study of Patients with Migraine Treated with Fremanezumab in South Korea.
Fremanezumab is being evaluated for its safety and effectiveness in South Korea. This study focuses on adults with migraines using fremanezumab for the first time. It is a 6-year, non-interventional study across 60…