Chronic Migraine Research
Explore research on chronic migraine, migraine chronification, treatment and outcomes.
-
Effect of chronic migraine treatment on functional seizure frequency: An exploratory study.
Authors: Kyrgyzbay G, Kasenova A, Ornello R, Alzhanova D, Utebekov Z Clinical trial
Chronic migraine often coexists with functional seizures, which are challenging to manage. This study aimed to see if migraine treatment impacts seizure frequency in patients. Researchers selected patients suffering…
-
TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review).
Authors: Zhang M, Pu Y, Zhang Y, Hu J, Li S Laboratory / animal study
Migraines are common and debilitating neurological disorders affecting many people. Central sensitisation is the main cause of their recurrent and chronic nature. Transient receptor potential vanilloid 1, or TRPV1…
-
Long-term neuromuscular alterations during botulinum toxin treatment for chronic migraine.
Authors: Plensäll T, Liik M, Pogosean A, Eriksson A, Garrett M Clinical trial
This study examined the effects of botulinum toxin type A on chronic migraine. Forty women with chronic migraine received varying lengths of BoNTA treatment. Researchers evaluated migraine frequency, pain burden, and…
-
Galcanezumab in chronic migraine
Authors: Detke et al. Clinical trial
This study evaluated galcanezumab's effectiveness for preventing chronic migraines. Galcanezumab is a humanized monoclonal antibody targeting calcitonin gene-related peptide. It was tested in a phase 3, randomized…
MigraineMind Top 100 · #55 -
Fremanezumab for the Preventive Treatment of Chronic Migraine
Authors: Silberstein et al. Clinical trial
Fremanezumab is a monoclonal antibody aimed at preventing chronic migraines. This study compared its effectiveness to placebo in a phase 3 trial. Patients with chronic migraines received one of three treatments. They…
MigraineMind Top 100 · #26 -
Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial
Authors: Tepper et al. Clinical trial
The study explored erenumab's safety and efficacy in chronic migraine patients. Researchers conducted a phase 2, randomized, double-blind trial across 69 centers in North America and Europe. Participants were adults…
MigraineMind Top 100 · #32 -
Chronic migraine: risk factors, mechanisms and treatment
Authors: May et al. Review
Chronic migraine significantly impacts patients' lives, affecting their quality and socioeconomic functioning. It affects 1-2% of the general population and 8% of migraine patients. Chronic migraine usually develops…
MigraineMind Top 100 · #56 -
OnabotulinumtoxinA for treatment of chronic migraine: Results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trial
Authors: Aurora et al. Clinical trial
This study investigates the effectiveness of onabotulinumtoxinA for chronic migraine treatment. It is part of the PREEMPT 1 trial, focused on safety and efficacy. The study lasted 24 weeks and included a…
MigraineMind Top 100 · #22 -
OnabotulinumtoxinA for Treatment of Chronic Migraine: Pooled Results From the Double‐Blind, Randomized, Placebo‐Controlled Phases of the PREEMPT Clinical Program
Authors: Dodick et al. Clinical trial
This research investigates onabotulinumtoxinA, commonly known as BOTOX, for chronic migraine treatment. Chronic migraine is a common, debilitating condition that often remains untreated. The study pooled results from…
MigraineMind Top 100 · #29 -
Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers
Authors: Buse et al. Observational study
This research aimed to compare the sociodemographic profiles of chronic migraine and episodic migraine sufferers. The study analyzed data from the AMPP survey, which included 24,000 headache sufferers. Among them…
MigraineMind Top 100 · #73 -
Global prevalence of chronic migraine: A systematic review
Authors: Natoli et al. Systematic review / meta-analysis
This review aimed to summarize studies on chronic migraine (CM) prevalence. Researchers conducted a systematic search for relevant population-based studies. Sixteen publications were accepted, representing twelve…
MigraineMind Top 100 · #64 -
Acute Migraine Medications and Evolution From Episodic to Chronic Migraine: A Longitudinal Population‐Based Study
Authors: Bigal et al. Observational study
This study explores how acute migraine medications affect the transition from episodic migraine (EM) to chronic migraine (TM). Researchers followed 8219 EM patients over five years. They found that 2.5% developed TM…
MigraineMind Top 100 · #49 -
Topiramate Reduces Headache Days in Chronic Migraine: A Randomized, Double-Blind, Placebo-Controlled Study
Authors: Diener et al. Clinical trial
This study investigated the effectiveness of topiramate for chronic migraine prevention. Chronic migraine affects many individuals and causes significant disability. Preventive treatments are crucial, but data on…
MigraineMind Top 100 · #88 -
New Appendix Criteria Open for a Broader Concept of Chronic Migraine
Authors: Olesen et al. Guideline / consensus
Chronic migraine (CM) and medication overuse headache (MOH) diagnoses have changed recently. Very few patients fit the previous diagnostic criteria for CM. The old system required discontinuation of medication…
MigraineMind Top 100 · #41