Chronic Migraine Research
Explore research on chronic migraine, migraine chronification, treatment and outcomes.
-
Cluster Analysis of Global Research Hotspots and Thematic Evolution in Chronic Migraine: A Bibliometric Study (1917-2024).
Authors: Chen H, Chen Q, Yang Y, Yu Q, Pan Y Laboratory / animal study
Chronic migraine is a common and debilitating neurological condition affecting many people. This study examined research trends on chronic migraine from 1917 to 2024. Researchers used cluster analysis to identify…
-
A status update on the unkept promise of high-frequency spinal cord stimulation for treatment-refractory chronic migraine.
Authors: Martelletti P, Tana C Case report / case series
Chronic migraine is a challenging condition, especially when treatments fail. High-frequency spinal cord stimulation (HF-SCS) is a new approach for these patients. This method uses a frequency of 10 kilohertz, which…
-
Comorbidity of Temporomandibular Disorders, Anxiety, Depression, and Poor Sleep Quality in Episodic and Chronic Migraine: A Cross-Sectional Observational Study.
Authors: Torrijos-Gómez G, Florencio LL, Cuadrado ML, Ardizone I, Porta-Etessam J Observational study
This study looked at the link between temporomandibular disorders (TMD) and migraine. Researchers focused on two types of migraine: episodic migraine (EM) and chronic migraine (CM). They wanted to see if TMD made…
-
Greater Mediterranean Diet Adherence Is Associated with Lower Odds of Chronic Migraine: A Retrospective Observational Study.
Authors: Alis C, Uludüz E, Eyüpoğlu S, İskender M, Öztornacı O Observational study
This study explored how following a Mediterranean diet (MD) affects migraines. Researchers looked at 448 patients with migraines, both episodic and chronic. They measured MD adherence using a specific questionnaire…
-
Distinct brain metabolic patterns reflect biological heterogeneity and relate to clinical outcome in chronic migraine with medication overuse.
Authors: Liu HY, Yeh HH, Lee PL, Chen IJ, Liao YH Observational study
Chronic migraine with medication overuse (CMwMO) can be very disabling. This condition shows varied responses to treatments and medication withdrawal. Researchers studied brain metabolic patterns in CMwMO patients…
-
Comparison of the Effectiveness of Greater Occipital Nerve (GON) Block and Sphenopalatine Ganglion (SPG) Block in the Treatment of Chronic Migraine.
Authors: Kierońska-Siwak S, Meder G, Dzierżanowski M, Wiśniewski J, Jabłońska M, Grzanka D Observational study
Chronic migraine significantly affects quality of life and can be debilitating. This study compared the effectiveness of greater occipital nerve (GON) block and sphenopalatine ganglion (SPG) block. It involved 50…
-
Association of transverse sinus stenosis and dominant venous sinus drainage pattern with chronic migraine: A matched case-control study.
Authors: Xiang X, Zhu S, Liu X Observational study
Transverse sinus stenosis (TSS) may be important for chronic migraine (CM). This study included 94 CM patients and 94 matched controls. All participants underwent magnetic resonance venography to assess their venous…
-
Normative structural MRI deviation factors summarize patient-level neuroanatomical heterogeneity across episodic and chronic migraine.
Authors: Dai C, Ye M, Li X, Yan Z, Ye L Observational study
In migraine research, structural MRI findings vary widely among different groups. This inconsistency may hide important patient-level differences in neuroanatomy. To explore this, we studied 249 adults with migraines…
-
Hormonal, metabolic, and stress-related clinical differences between episodic and chronic migraine: insights for diagnostic and therapeutic approaches.
Authors: Gozubatik-Celik RG, Uludüz E, Eyüboğlu S, İskender M, Sungur MA Observational study
Migraine is a common neurological disorder with episodic (EM) and chronic (CM) forms. This study focused on hormonal and metabolic differences between these two groups. Researchers analyzed data from 500 patients…
-
Self-assembled nanoaggregates in Wuzhuyu decoction: formation, absorption, transport, and alleviation of chronic migraine.
Authors: Wang Q, Guo X, Li M, Nan N, Zhang Z Laboratory / animal study
Self-assembled nanoaggregates (SANs) from herbal decoctions show promise as natural medicines. Wuzhuyu decoction (WZYD) is a traditional formula for treating migraines. This study focuses on how SANs in WZYD, called…
-
Late-pregnancy oxytocin alleviates neuroinflammation and hyperalgesia in chronic migraine model via PVN to NTS oxytocinergic projections and ECM-receptor interaction signaling.
Authors: Wang L, Zeng Z, Zhou Y, Gu C, Zhang Y Laboratory / animal study
Migraine is a common neurological disorder causing recurrent headaches. Female migraine patients often report less headache severity and frequency during late pregnancy. However, the reasons behind this phenomenon…
-
IRAK-M attenuates pain hypersensitivity and anxiety-like behaviors in a nitroglycerin-induced chronic migraine mouse model with concomitant reductions in microglial activation and neuroinflammation.
Authors: Liang XT, Xie SR, Liu XM, Zhu XY, Xiong YF Laboratory / animal study
Chronic migraine is a debilitating neurological condition involving neuroinflammation and central sensitization. This study focused on interleukin-1 receptor-associated kinase M (IRAK-M) in chronic migraine. IRAK-M…
-
Periaqueductal gray matter echogenicity: An irreversible marker of chronic migraine?
Authors: Flores-Pina B, Vilas Rolán D, Ríos Guillermo J, Gea Rispal M, Rubio-Guerra S Observational study
This study investigated the periaqueductal gray matter (PAG) in migraine patients. Researchers aimed to see if PAG changes correlate with migraine classification shifts. They reanalyzed data from 115 participants…
-
Chronic migraine management with onabotulinumtoxinA and anti-CGRP/R monoclonal antibodies in an Italian real-world setting: update on therapeutic appropriateness and an emerging role of pharmacy.
Authors: Scuteri D, Naturale MD, Pagliaro M, Brescia A, De Francesco AE Guideline / consensus
Migraine is a challenging neurovascular disorder that can progress to chronic forms. This progression may result in medication-overuse headache, leading to higher healthcare costs. The need for preventive treatments…
-
Targeted liquid chromatography-tandem mass spectrometry profiling of arginine and histidine derivatives in chronic migraine: Discriminatory performance and changes after onabotulinumtoxinA therapy.
Authors: Dumur S, Diarra K, Sewidan J, Kalmoni JJ, Aygun D Observational study
This study explored the role of specific amino acids in chronic migraine patients. Researchers evaluated plasma levels of arginine, histidine, and their derivatives. They aimed to identify potential biomarkers for…
-
Dual-attention temporal graph neural network on resting-state fMRI dynamic functional connectivity identifies risk-related patterns of migraine chronification.
Authors: Xu CY, Zhan SH, Gong Z, Zhang M, Wu Y Observational study
Migraine chronification is challenging to characterize on an individual basis. There are no robust imaging markers for the conversion from episodic migraine to chronic migraine. This study involved 195 participants…
-
Paeoniae Radix Alba-Chuanxiong Rhizoma herbal pair alleviates trigeminal nucleus caudalis neuroinflammation in chronic migraine associated with P2Y12R/PPARγ-related NF-κB signaling.
Authors: Liu L, Feng M, Liu J, Cai S, Cong S Laboratory / animal study
Chronic migraine involves neuroinflammation in the trigeminal nucleus caudalis, or TNC. The herbal pair Paeoniae Radix Alba and Chuanxiong Rhizoma is commonly used for treatment. This study examined the effects of…
-
Peptidomics profiling identifies endogenous peptides associated with meningeal afferent activation in a chronic migraine mouse model.
Authors: Zhao G, Duan C, Gui Y, Wang H, Zhao J Laboratory / animal study
Migraine is a disabling disorder that affects many people worldwide. It significantly impacts quality of life due to its debilitating symptoms. Recent studies suggest that endogenous peptides play vital roles in…
-
Efficacy of prefrontal-occipital transcranial direct current stimulation for refractory chronic migraine.
Authors: Nazanin RA, Elham J, Mansoureh T, Azam B Observational study
Patients with chronic migraine often do not respond to standard medical treatments. This resistance likely comes from the complex nature of their pain. Transcranial direct current stimulation, or tDCS, is a new…
-
Thiamine deficiency in patients with chronic migraine: A case-control study.
Authors: Prakash S, Vadodaria V, Yadav M, Patel SM Observational study
Thiamine deficiency is noted in various neurological disorders, including chronic migraine (CM). This study aimed to compare serum thiamine levels in CM patients and healthy controls. A total of 100 adults with CM…